Discovery Chemistry

At Devsynthesis, we stand at the forefront of drug discovery chemistry services, harnessing the exceptional skills of our accomplished scientists and cutting-edge infrastructure. Our team of drug discovery chemists boasts an impressive wealth of expertise, particularly in the realm of multi-step organic synthesis spanning multiple therapeutic domains. Their contributions play a pivotal role in our comprehensive and synergistic discovery programs, propelling us towards innovative and functional solutions for our clients.

• We design of route and synthesis support for the “Novel Chemistry Targets” under the CDA and MSA as focused libraries / different scaffolds of desired skeleton to support NCE
• The synthesis of multi-step complex chemistry molecules at mg scale to few grams scale for “clients to check for quick metabolic stability” and bioactivities of required lead molecules.
• The targets under these FTE service will be made very quicky to support clients “NCE/ NDDS projects”
• We support all difficult to perform / rare to make chemistry molecules under this category of service.
• We deliver chemistry targets much faster with >95% LCMS and clean HNMR data.

Hit-to-Lead

With years of scientific expertise and drug discovery experience under our belts, our scientists can turn hits into high-potency leads quickly to advance them to the lead optimization phase. Our team meticulously assesses hits for factors such as potency, selectivity, and drug-likeness, ensuring that only the most promising compounds proceed to the next stages. Our years of drug discovery experience empowers us to design analogs with improved drug likeness, adding value to the program.

Route Scouting and Focused Library Synthesis: Our expertise extends to route scouting and the synthesis of focused libraries, providing a versatile toolkit to explore and generate compounds of interest.

Lead optimization

Using the identified lead compound from the hit-to-lead stage, our scientists work on optimizing and evaluating the leads through various screening studies until a suitable preclinical candidate is ready. Our lead optimization capabilities include:

• Design of hypothesis to optimize hits for desired potency and efficacy
• Multi-parameter optimization of leads
• Optimization studies for potency, selectivity, in vivo efficacy, pharmacokinetic/ pharmacodynamics modeling (PK/PD) profile, safety and toxicity profile
• Early scale-up of molecules to support in vivo efficacy and toxicity studies
• Selection of preclinical candidates